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Macromodel
LigPrep Schrodinger LiveDesign Glide Jaguar Scripting Phase Quantum Mechanics
  1. Go to item
    Workflow
    Library design workshop
    Library Design MacroModel
    Bioisostere and R-group enumeration using custom or predefined isosteres and libraries. Reaction-Based Enumeration to rapidly gen…
    schroedinger > Workflow_examples > Library design > Library design workshop > Library design workshop
    1
    schroedinger
  2. Go to item
    Workflow
    Torsion_profiles
    Schrodinger MacroModel LigPrep
    +1
    Performes a torsion scan for a defined dihedral using MacroModel and returns the energy profile. 22.2.4
    schroedinger > LiveDesign_models > Plotting > Torsion profiles
    0
    schroedinger
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    Workflow
    Docking and ligand strain
    LiveDesign Glide LigPrep
    +2
    Docks the compounds with Glide. The docking pose are minimized to a local minimum and a conformational search is run to find the …
    schroedinger > Internal development > 23-1 > Docking with core constraint
    0
    schroedinger
  4. Go to item
    Workflow
    Torsion_profiles
    Schrodinger MacroModel LigPrep
    Performes a torsion scan for a defined dihedral using MacroModel and returns the energy profile. To define the dihedral, a smarts…
    schroedinger > Internal development > 22-3 > Torsion_scan > Torsion_profiles --- 0901 JK
    0
    schroedinger
  5. Go to item
    Workflow
    Torsion_profiles
    Schrodinger MacroModel LigPrep
    Performes a torsion scan for a defined dihedral using MacroModel and returns the energy profile. To define the dihedral, a smarts…
    schroedinger > Internal development > 22-3 > Torsion_scan > Torsion_profiles
    0
    schroedinger
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    Workflow
    Conformational Search and Quantum Mechanics Refinement
    Quantum Mechanics MacroModel Jaguar
    Conformers generated with MacroModel are refined with Jaguar. They are then compared in terms of geometry and Boltzmann populatio…
    schroedinger > Workflow_examples > Quantum Mechanics > Conformational search > QM Conformational search 1
    0
    schroedinger
  7. Go to item
    Workflow
    Torsion_profiles_reference
    Schrodinger LigPrep MacroModel
    Performes a torsion scan for the input and a reference molecule for a defined dihedral using MacroModel and returns the energy pr…
    schroedinger > Internal development > 22-3 > Torsion_scan > Torsion_profiles_reference --- 0901 JK
    0
    schroedinger
  8. Go to item
    Workflow
    Parameter flow variable use-cases
    Labs MacroModel Phase
    +4
    Use the parameter flow variables to control command-line options not exposed in the configuration panel. This is illustrated for …
    schroedinger > Workflow_examples > Labs > Parameter flow variables > Parameter flow variables 1
    0
    schroedinger
  9. Go to item
    Workflow
    Compare Conformational Search Methods
    Molecular Mechanics MacroModel ConGen
    +2
    Run a conformational search with various methods and compare the lowest energy conformers. Parse the log file to extract relevant…
    schroedinger > Workflow_examples > Molecular Mechanics > Compare confo search methods > Compare confo search methods
    0
    schroedinger
  10. Go to item
    Workflow
    Torsion_profiles_overlay-plots
    Schrodinger MacroModel LigPrep
    Performes a torsion scan for a defined dihedral using MacroModel and returns the energy profile. To define the dihedral, a smarts…
    schroedinger > Internal development > 22-3 > Torsion_scan > Torsion_profiles_overlay-plots --- 0901 JK
    0
    schroedinger
  11. Go to item
    Workflow
    Chemistry External Tool Node Use-cases
    Scripting Maestro Phase
    +1
    The Chemistry external tool nodes can be used to parse a log file with basic shell commands, run Shrodinger utilities or backends…
    schroedinger > Workflow_examples > Scripting > Chemistry external tool > Chemistry external tool 1-2
    0
    schroedinger
  12. Go to item
    Workflow
    Parameter flow variable use-cases
    Labs MacroModel Phase
    +4
    Use the parameter flow variables to control command-line options not exposed in the configuration panel. This is illustrated for …
    schroedinger > Workflow_examples > Labs > Parameter flow variables > Parameter flow variables 1-2
    0
    schroedinger
  13. Go to item
    Workflow
    Low energy conformations
    LiveDesign LigPrep MacroModel
    +2
    It runs a MacroModel or ConfGen conformational search on structures prepared with LigPrep. Optionally align them on a reference t…
    schroedinger > LiveDesign_models > Docking post-processing > Low energy conformations
    0
    schroedinger
  14. Go to item
    Workflow
    Run Maestro Command Node Use-cases
    Scripting Maestro Macromodel
    The Run maestro command node is used to alter the formal charge of some atoms defined by an ASL and for altering the structure re…
    schroedinger > Workflow_examples > Scripting > Maestro commands > Maestro commands
    0
    schroedinger
  15. Go to item
    Workflow
    Output Column Structure Options Philosophy
    General MacroModel Glide
    Illustrate the Output column structure options (output only, input plus output, and output replaces input). The workflow also dem…
    schroedinger > Workflow_examples > General > Output column structure > Output column structure
    0
    schroedinger
  16. Go to item
    Workflow
    Docking and ligand strain
    LiveDesign Glide LigPrep
    +2
    Docks the compounds with Glide. The docking pose are minimized to a local minimum and a conformational search is run to find the …
    schroedinger > Internal development > 22-4 > validated_models > Docking > Docking and ligand strain
    0
    schroedinger
  17. Go to item
    Workflow
    Torsion_profiles
    Schrodinger MacroModel LigPrep
    +1
    Performes a torsion scan for a defined dihedral using MacroModel and returns the energy profile. 22.2.4
    schroedinger > Internal development > 22-4 > validated_models > Plotting > Torsion_profiles
    0
    schroedinger
  18. Go to item
    Workflow
    Python Script Node Use-cases
    Scripting Macromodel Python
    The Python Script nodes are used to extract ring properties, run a Macromodel conformational search with specific parameters, and…
    schroedinger > Workflow_examples > Scripting > Python script > Python script 1
    0
    schroedinger
  19. Go to item
    Workflow
    Conformational Search and QM Refinement
    Quantum Mechanics MacroModel Jaguar
    Conformers generated with MacroModel are refined with Jaguar. They are then compared in terms of geometry and Boltzmann populatio…
    schroedinger > Workflow_examples > Quantum Mechanics > Conformational search > QM Conformational search 1-3
    0
    schroedinger
  20. Go to item
    Workflow
    Python Script Node Use-cases
    Scripting Macromodel Python
    The Python Script nodes are used to extract ring properties, run a Macromodel conformational search with specific parameters, and…
    schroedinger > Workflow_examples > Scripting > Python script > Python script 1-2
    0
    schroedinger

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