This component performs a query for chemical structure searches using the SMILES notation. The component is based on the RCSB PDB RESTful WebServices. The chemical structure search query results in a list of PDB IDs and the associated ligand information (chemicalID). Additionally information like chemical name, smiles, molecular weight, formula, InChiKey and InChI of the respective ligand is provided. The output table also includes, a column with combined score of results from different services (sequence, seqmotif, strucmotif, structure, chemical, and text) and results are sorted in decreasing order of this score. The following search types are possible with the component: • graph-strict • graph-relaxed • graph-relaxed-stereo • fingerprint-similarity Documentation about the RESTful WebService from PDB can be found here: https://search.rcsb.org/index.html#search-services General information about the RCSB PDB database can be found here: https://academic.oup.com/nar/article/28/1/235/2384399