Run FVA

This node runs flux variability analysis (FVA) with selected set of reactions. FVA finds a range of flux values compatible with the objective optimum found by FBA. Usually model is allowed to deviate from the optimum by small fraction that is controlled by **Fraction of Optimum** parameter. If **Fraction of Optimum** is set to 0.99 then model can deviate no more than 1% from the optimum. Sometimes high absolute flux values in FVA observed for reactions that participate in loops. This is model structure artefact and to avoid such situation **Looples** option should be ticked, but that makes simulation much slower.

Run FVA accepts reaction IDs and vary only fluxes for reactions in the provided table. Reactions are connected to table rows by column selected as **Reaction ID** in the configuration dialog. In the case when the value in the **Reaction ID** column do not match any reaction in the model, that row will be omitted and no error or exception will be raised. If no reactions matches the table, empty table will be created and model will be returned unchanged.

Output of the FVA component is a table with three columns:
reaction ID and minimum and maximum of the allowed flux.

Input ports

1. Type: Python
   model
   Cobra Model object from other FBA components
2. Type: Table
   reactions
   table of reactions to vary

Output ports

1. Type: Table
   fluxes
   flux variability table
2. Type: Python
   model
   Cobra Model object from the input port of the component.