This component connects to an instance of the ChEMBL database and retrieves the number and names of chemical probes associated with a target. The input parameters are the column names for the target’s ChEMBL ID and mutation/variant type. Empty or missing values in the mutation/variant type column are assumed to represent the wild type and will be converted to "WT."
The definition of “chemical probe” follows the criteria used in ChEMBL, which sources definitions from chemicalprobes.org and probes-drugs.org. Chemical probes are linked to a target only if they have a documented mechanism of action (MOA) relationship with the target or exhibit a potency of ≤ 1 µM (i.e., pChEMBL value ≥ 6).
For this component to function, the ChEMBL DB Connection variables must be defined at the workflow level. These variables can be established using the ChEMBL DB Connection component.
The definition of “chemical probe” follows the criteria used in ChEMBL, which sources definitions from chemicalprobes.org and probes-drugs.org. Chemical probes are linked to a target only if they have a documented mechanism of action (MOA) relationship with the target or exhibit a potency of ≤ 1 µM (i.e., pChEMBL value ≥ 6).
For this component to function, the ChEMBL DB Connection variables must be defined at the workflow level. These variables can be established using the ChEMBL DB Connection component.