This component retrieves Mechanism of Action (MOA) and indication information for input biological targets. The targets are identified using their targert ChEMBL IDs.
The first output provides a summary of the MOA for each target, highlighting the diseases/indications associated with the target MOA through its related drugs. This port output also the input target ChEMBL iDs that have no MOA information.
The second output presents detailed information about the target MOA. Each target-MOA may be associated with various approved (i.e., phase 4) or investigational (i.e., 0 < phase < 4) drugs. References regarding the target-MOA-drug associations are also included. This outport is inactive if all the input targets have no associated MOA data.
The third output offers detailed information about the approved and investigational drugs associated with the target MOAs reported in the second output, specifying all the therapeutic indications for which these drugs are used or being tested. For each drug-disease pair, the maximum phase reached by the drug is also provided. Finally, references for this information are included. This outport is inactive if all the input targets have no associated MOA data.
For this component to function, the ChEMBL DB Connection variables must be defined at the workflow level. These variables can be established using the ChEMBL DB Connection component.
The first output provides a summary of the MOA for each target, highlighting the diseases/indications associated with the target MOA through its related drugs. This port output also the input target ChEMBL iDs that have no MOA information.
The second output presents detailed information about the target MOA. Each target-MOA may be associated with various approved (i.e., phase 4) or investigational (i.e., 0 < phase < 4) drugs. References regarding the target-MOA-drug associations are also included. This outport is inactive if all the input targets have no associated MOA data.
The third output offers detailed information about the approved and investigational drugs associated with the target MOAs reported in the second output, specifying all the therapeutic indications for which these drugs are used or being tested. For each drug-disease pair, the maximum phase reached by the drug is also provided. Finally, references for this information are included. This outport is inactive if all the input targets have no associated MOA data.
For this component to function, the ChEMBL DB Connection variables must be defined at the workflow level. These variables can be established using the ChEMBL DB Connection component.