KNIME - use openpyxl to set password on Excel There are limited ways to protect an Excel file using the Python package [ openpyxl](https://openpyxl.readthedocs.io/en/stable/protection.html). But it would only offer protection from some changes (not from opening the file) and the password would be stored hashed - so no real hurdle there. In general I think most password protections for Office files are more there to prevent accidental editing to keep a fixed structure - but they are insufficient for real protection
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