This component retrieves target tractability information using Ensembl gene IDs, providing insights into the druggability of specific biological targets.
If one or more requests result in erroneous or empty responses, missing values will be output in the additional columns, but all rows will still be included in the output. Erroneous requests will be provided through the second output port.
WARNING: Currently, this component retrieves tractability information only for small molecules.
Open Targets small molecule tractability legend:
- Structure with Ligand: Target has been co-crystallised with a small molecule (source: PDB)
- High-Quality Ligand: Target with ligand(s) (PFI ≤ 7, SMART hits ≤ 2, scaffolds ≥ 2) (source: ChEMBL)
- High-Quality Pocket: Target has a DrugEBIlity score of ≥ 0.7 (source: DrugEBIlity)
- Med-Quality Pocket: Target has a DrugEBIlity score between 0 and 0.7 (source: DrugEBIlity)
- Druggable Family: Target is considered druggable as per Finan et al’s Druggable Genome pipeline (source: https://pubmed.ncbi.nlm.nih.gov/28356508/).
If one or more requests result in erroneous or empty responses, missing values will be output in the additional columns, but all rows will still be included in the output. Erroneous requests will be provided through the second output port.
WARNING: Currently, this component retrieves tractability information only for small molecules.
Open Targets small molecule tractability legend:
- Structure with Ligand: Target has been co-crystallised with a small molecule (source: PDB)
- High-Quality Ligand: Target with ligand(s) (PFI ≤ 7, SMART hits ≤ 2, scaffolds ≥ 2) (source: ChEMBL)
- High-Quality Pocket: Target has a DrugEBIlity score of ≥ 0.7 (source: DrugEBIlity)
- Med-Quality Pocket: Target has a DrugEBIlity score between 0 and 0.7 (source: DrugEBIlity)
- Druggable Family: Target is considered druggable as per Finan et al’s Druggable Genome pipeline (source: https://pubmed.ncbi.nlm.nih.gov/28356508/).